Consumption, leprosy, rectal prolapse, abdominal distension, indigestion and other diseases are destroyed in one who practices Mahāmudrā.

The text lists various ailments that Mahāmudrā can cure: kṣaya (consumption, tuberculosis), kuṣṭha (leprosy or skin diseases), gudāvarta (rectal prolapse or anal disorders), gulma (abdominal distension, tumors), ajīrṇa (indigestion).

From the perspective of Haṭha Yoga, these diseases arise from imbalances in the doṣas (vāta, pitta, kapha) and blockages in the flow of prāṇa.Mahāmudrā, by activating Mūlādhāra, applying bandhas and directing prāṇa, harmonizes these elements.

The Bihar School interprets these benefits as a result of stimulating the digestive system, improving pelvic circulation and activating the autonomic nervous system.Regular practice can certainly improve overall health, although the claims in the text must be contextualized historically.