Even if you are the most sinful of all sinners, you will cross the ocean of sin by the boat of knowledge.

Redemptive power of knowledge. Api cet — even if — indicates that no case is lost.

Pāpa-kṛt-tamaḥ — the most sinful — is the extreme, including all less virtuous. Jñāna-plavena — by the boat of knowledge — vṛjinam — the ocean of difficulty/sin — is crossed. Santariṣyasi — you will cross — indicates certainty. Knowledge is a more powerful force than past karma.