Therefore, oh bull among the Bharatas, first master the senses and destroy this sin, which destroys knowledge and realization.

Practical solution: niyamya — master, subdue — indriyāṇi first.

Pāpmānam — sin personified — is kāma (desire), which is jñāna-vijñāna-nāśanam — destroys theoretical knowledge and realized knowledge. Jñāna is knowing; vijñāna is direct, experiential knowledge. The enemy destroys both, leaving only empty belief or ignorance.