Through various asanas, kumbhakas and other various practices, when the great śakti awakens, prāṇa dissolves into emptiness.

This verse connects the practices of the previous chapters with the goal of samādhi:

Vividhaiḥ āsanaiḥ — the various postures of Chapter 1. Kumbhaiḥ — the respiratory retentions of Chapter 2. Vicitraiḥ karaṇaiḥ — the various techniques (mudrās, bandhas) of Chapter 3.

All these practices have a common purpose: to awaken mahāśakti, the great energy.

Prabuddhāyām — when he wakes up.Kuṇḍalinī is frequently described as asleep in mūlādhāra.The practices awaken it and make it rise.

Prāṇaḥ śūnye pralīyate — prāṇa dissolves in emptiness.When kuṇḍalinī rises completely, the prāṇa that normally flows through iḍā and piṅgalā enters suṣumnā and finally dissolves into sahasrāra.

This dissolution is samādhi.The movement of energy ceases;Consciousness remains in its natural state, without the fluctuations caused by pranic flow.

The verse synthesizes the entire methodology of haṭha yoga in a sequence: techniques → awakening of śakti → dissolution of prāṇa → conscious emptiness.